The Spanish synagogue is situated few steps from the Old Town Square in the Old Town, right bank of the river Vltava. From the Old Town Square when following Pařížská Street in the middle turn to the right; the Spanish synagogue then will be after 200 meters on your left.
Nearby public transportation – the bus (207) and tram (17) stops “Právnická fakulta” and also metro station Staroměstská - from here you follow Kaprova Street up to the Old Town Square, the rest is the same as described above.